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Currently, several preclinical models of PTSD are in use to explore subsets of traits altered in PTSD and potential interventions targeting resilience or recovery from trauma.
Keywords: PTSD, pre-clinical, animal models, preclinical Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements.
Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients.
Yet, much remains unknown about pathophysiology and why some individuals recover from trauma while other develop pathological responses. Posttraumatic stress disorder (PTSD) affects up to 7-8% of individuals in the United States causing moderate to severe impairment in over two thirds of patients.
We encourage authors to submit original research manuscripts, but we will consider reviews or perspective pieces that offer novel perspective or conceptual development.
Authors should highlight how their submission relates to the aforementioned goals of this special edition and the theme of preclinical models of PTSD.However, studies on CPTSD directly are nearly non-existent. By using neuroimaging techniques and tools such as f MRI, scientists are getting closer to understating how badly trauma impacts both children and adults. Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder. Not only were those brain regions affected, but regions that control intellect, such as the corpus callosum (the wiring of the brain) and smaller than average frontal lobe volume (the seat of intelligence) (Karl, Schaefer, et. (2006).3Researchers have conducted many research projects using different modes of neuroimaging, including f MRI, PET, and newer forms of visualizing the brain come into existence every year (Bremner, Randall et. A study examined, with the then-new neuroimaging tool functional magnetic resonance imaging (f MRI) in 1980 revealed smaller than normal volumes in both the hippocampi and amygdalae of people living with the diagnosis of PTSD. What this study shows is how two vital regions of the brain associated with emotional regulation and memory consolidation are damaged when exposed repeatedly to traumatic stress.4, 5Mental health professionals are currently trying to decide if CPTSD is its own disorder, or if it belongs to a spectrum of trauma disorders. There have been some truly remarkable research papers written about complex post-traumatic stress disorder (CPTSD) in the past few decades.Some of the research focuses exclusively on CPTSD while others can apply to any mental health disorder.These two life-altering disorders affect fifty to seventy percent of the citizens of the United States and cost America over forty billion dollars per year. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.The suffering and impact on families and communities are profound, leaving many adults unable to cope with their lives and losing the ability to work well (Brenner, (2018)2. Children who grow up under stress from living in a dysfunctional family where they experienced some type of abuse or neglect, grow up with significant changes in their brains. Since they have damage to their hippocampi and amygdalae, they have problems regulating their emotions and overreacting to triggers in their adult environment that cause conflict in forming adult relationships.